Objectives:

Perform the overall legal, ethical, financial and administrative management 

• Manage contract and consortium agreement issues  
• Maintain records of cost and effort 
• Monitor the compliance of partners with obligations 
• Define internal PHOREVER controls 
• Facilitate communication and co-operation between the partners 
• Provide technical planning with up-to-date contingency plan 
• Perform innovation management and response to opportunities 
• Prepare periodic management and technical progress reports 
• Provide a point of communication with the EC 
• Prepare the scheduled PHOREVER reviews 
• Ensure that equal opportunities are offered to both genders

Objectives:

• Define the use cases for PHOREVER multi-sensing platform and specify the corresponding high-level system requirements 
• Translate the system requirements into designs of the PHOREVER modules and define the system-level specifications of their individual components 
• Define the process steps for the integration of the individual components and the packaging of PHOREVER modules (main and contingency plans) and consolidate these steps into a cohesive process flow 
• Develop system models for the individual components and modules of PHOREVER and platforms for the simulation of their system performance 
• Develop methods and algorithms for the calibration, configuration and operation of PHOREVER modules 
• Develop AI-based algorithms for the data analysis from the FCM module

Objectives:

• Develop the SS-OCT external cavity tunable laser 
• Design and deliver the micro-optic elements to be integrated with the TriPleX® PICs 
• Develop a photonic integrated circuit (PIC) based on on-chip flow-cytometry using fluorescence and scatter-based technique for detection of particles with a diameter down to 140 nm 
• Develop a photonic integrated circuit (PIC) as the core of a swept source optical coherence tomography (SS-OCT) sensing module using swept source OCT approach 
• Develop bulk control electronics for use in the TriPleX PIC testing 
• Basic characterization of TriPleX FCM and OCT PICs

Objectives:

• Development of a process flow for the blood sample handling towards plasma generation and EV tagging
• Translation of the blood handling protocol into the pre-analytical and analytical stage fluidic chip 
• Develop the microfluidic chip enabling particle focusing (passively & actively), EV pre-concentration and EV analysis 
• Manufacturing of fluidic cartridges 
• Evaluation of the fluidic cartridges with reference samples 
• Evaluation of the fluidic cartridges with real samples

Objectives:

• Define packaging approach and methodology for TriPleX® sensing PICs 
• Integration of the micro-optic elements
• Hybrid integration of the TriPleX PICs 
• Assembly and packaging of photonic FCM and OCT sensing modules 
• Deliver PHOREVER precursor prototype 
• Develop the driving and control electronics for PHOREVER platform 
• Develop the firmware of the PHOREVER platform 
• Assembly and packaging of PHOREVER multi-sensing platform into the final prototype 
• Deliver PHOREVER final prototype

Objectives:

• Collect blood samples from cancer patients and cardiovascular patients 
• Generate biobank with the collected human blood samples 
• Define metrics and thresholds for the measurement procedures compared also to measurements with gold-standard equipment 
• Identify EVs as possible biomarkers for the cancer use case 
• Identify EVs as possible biomarkers for the cardiovascular use case 
• Clinical validation of PHOREVER platform with spiked/reference samples 
• Clinical validation of PHOREVER platform with blood samples from patients.

Objectives:

• Organize the plans of the partners for exploitation of the project foreground knowledge at the technology, component and system level 
• Monitor the relevant IP across the globe and assess the possible threats
• Consolidate and protect the IP that will be generated in the project 
• Evaluate the process flow of PHOREVER and make a manufacturability analysis 
• Create a roadmap with concrete steps for the introduction of PHOREVER technology as a PoC device in health sector 
• Promote the interaction with other European and national projects 
• Disseminate results to the scientific community, industry, stakeholders and general public 
• Implement the open access policy via the deposition of generated data sets to open access repositories 
• Set up the website, prepare a promotion video and facilitate the rest of the dissemination activities 

Objectives:

The objective is to ensure compliance with the ‘ethics requirements’ set out in this work package